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KMID : 0356820070230020153
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Korean Journal of Head & Neck Oncology
2007 Volume.23 No. 2 p.153 ~ p.156
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A Case of Pharmacokinetics of Cisplatin in Concurrent Chemoradiation for Hemodialysis Patient with Advanced Head and Neck Cancer
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Chun Yeon-Joo
Shim Byoung-Yong
Kim Hyung-Wook
Lee Sang-Hun
Lee Ho-Sang
Park Cheol-Whee
Kim Su-Zy
Kuh Hyo-jeong
Kim Hoon-Kyo
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Abstract
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Objective : We study the feasibility and pharmacokinetics of cisplatin concurrent chemoradiation for advanced head and neck cancer patient undergoing hemodialysis.
Materials & Methods : A 57-year old male with end stage renal disease developed stage III external auditory canal cancer. Complete resection surgery was done. Postoperative 6 months, local recurrence was occurred. Despite excision and adjuvant radiotherapy, local tumor was recurred. We decided to treat a cisplatin concurrent chemoradiotherapy. Cisplatin was administered at a dose of 20mg/m^2 for 30 min. Hemodialysis was started 30 min after completion of the cisplatin infusion and performed for 4 hours. Hemodialysis was performed on day 3 and 5 of chemotherapy. Plasma samples were collected at specified times after administration of cisplatin.
Results : At the end of the third cycle of cisplatin concurrent chemoradiotherapy, the tumor size was markedly decreased. The maximum plasma concentrations of plasma platinum and free platinum were 0.74 and 0.37{mu}g/ml respectively. The area under the curve of plasma platinum and free platinum were 94.7 and 11.3{mu}g{cdot}h/ml respectively.
Conclusion : We report a case of Cisplatin concurrent chemoradiation for hemodialysis patient with advanced head and neck cancer and suggest full dose cisplatin concurrent chemoradiotherpay is tolerable for these patients.
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KEYWORD
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Pharmacokinetics, Cisplatin, Head and neck cancer, Hemodialysis
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